Pharmacokinetics of Moxifloxacin in Goats: Effect of Bifenthrin

Pharmacokinetics of moxifloxacin @ 5mg.kg-1.b.wt was studied in healthy and bifenthrin intoxicated goats (n=4), following its IV administration. The MIC of moxifloxacin in plasma was maintained up to 8h in healthy goats whereas it was maintained only up to 6h in bifenthrin-intoxicated goats. The AUC was significantly decreased from 7.86±0.06g.ml-1h to 6.90±0.076g.ml-1h in bifenthrin-intoxicated goats. The distribution half-life (t½) and volume of distribution at steady state Vd(ss) ¬observed were 0.08±0.0008 h and 2.43±0.01L.kg-1 respectively in healthy goats and 0.081±0.0006h and 2.32±0.03L.kg-1 in bifenthrin intoxicated goats. Total body clearance was increased from 636.06±4.68 ml.kg-1h-1 in healthy to 725.4±7.92 ml.kg-1h-1 in intoxicated goats. However, decrease in elimination half life (t1/2) from 2.81±0.04h to 2.61±0.01h was observed in intoxicated goats. The dosage regimen of moxifloxacin calculated in healthy animals is 4.99 mg.kg-1 followed by 4.73 mg.kg-1 at 12h interval effective against bacterial isolates with MIC ≤ 0.1µg.ml-1. However, in intoxicated goats, it is 6.66 mg.kg-1 followed by 6.33 mg.kg-1 at 12h interval.